The church is one of city’s largest and has a neo-Gothic facade added in the 19th century heavily decorated.

The building, attributed to Arnolfo di Cambio, has a majestic interior with a nave separated from the two aisles by slender octagonal pilasters supporting the broad pointed arches with a double cornice. At the end of the nave, with its open timber roof, is the transept with the chapels. The internal wall of the facade contains a stained-glass window with the Deposition, done from a cartoon by Lorenzo Ghiberti. Below, on the right is the monument to Gino Capponi by Antonio Bortone, while om the left, is the monument to G.B. Niccolini, historian and poet, by Pio Fedi.

On the wall are the funeral monuments to Michelangelo Buonarroti, by Vasari, to Dante Alighieri, by Stefano Ricci, to Vittorio Alfieri, by Canova, and to Niccolo Machiavelli by Innocenzo Spinazzi.

Museum of the works of Santa Croce consists of six rooms situated in what used to be the convent. The entrance room contains a fine fresco, Saint Francis distributing bread to the Friars, by Jacopo Ligozzi. The door on the right leads into a large hall dominated by a large fresco by Taddeo Gaddi of the Tree of Life.

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